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Tapentadol is primarily used for relief of moderate to severe acute pain, such as pain caused by injury, surgery, or medical procedures. It is also used for management of chronic pain in adults who require continuous treatment for an extended period of time. Tapentadol works by changing the way the brain and nervous system respond to pain. It is a centrally acting analgesic that combines opioid receptor agonism with noradrenaline reuptake inhibition.

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